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# Oleksandr Grygorenko Oleksandr Grygorenko

 Prof. Dr. Oleksandr Grygorenko, Head of the Organic Chemistry Department at the Chemical Faculty, Taras Shevchenko National University of Kyiv, Chief Scientific Officer at Enamine Scientific Research Institute, Consulting Scientist at Enamine Ltd

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## Сторінки

- [Welcome](https://grygorenko.com/) - Prof. Dr. Oleksandr Grygorenko, Head of the Organic Chemistry Department, Chemical Faculty, Taras Shevchenko National University of Kyiv, Consulting Scientist at Enamine.
- [Papers](https://grygorenko.com/publications/papers/)
- [CV](https://grygorenko.com/cv/) - Curriculum Vitae Year and place of birth 1982, Brody, Lviv region, Ukraine Education 2004–2007, Taras Shevchenko National University of Kyiv, Chemical Faculty, Ph.D. in Organic Chemistry1999–2004, Taras Shevchenko National University of Kyiv, Chemical Faculty, Master degree with distinction in Chemistry1996–1999, Ukrainian Physical Mathematical Liceum at Taras Shevchenko National University of Kyiv, Chemical Faculty, Golden Medal
- [Cover Pictures](https://grygorenko.com/publications/cover-pictures/) - Cover Pictures Shevchuk, O. I.; Vashchenko, B. V.; Doroshenko, I. O.; Stepannikova, K. O.; Hys, V. Yu.; Karpenko, O. V.; Kozachenko, O. P.; Cherepakha, A. Yu.; Kozytskyi, A.; Tolmachova, K. A.; Zhersh, S.; Tolmachov, A. O.; Grygorenko, O. O. Stability of heteroaromatic sulfonyl chlorides and fluorides. Chem. Eur. J. 2026, 32(13), e70739. DOI: 10.1002/chem.70739. Galavskyy, S.; Chernykh, A.
- [Research](https://grygorenko.com/research/) - Research The research is focused on developing chemical tools for drug discovery. My interest in this area emerged from the study of unnatural (mostly bicyclic) amino acids in the group of Prof. Igor Komarov back in 2000s. Currently, the focus is put on the design and synthesis of chemical building blocks (i.e., functionalized derivatives used
- [Books | Chapters](https://grygorenko.com/publications/books-chapters/) - Monographs Vashchenko, B. V.; Geraschenko, O.; Grygorenko, O. O. Heterocyclic α-oxoesters (hetaryl glyoxylates): synthesis and chemical transformations. Part 2. In: Targets in heterocyclic systems, Vol. 27; Attanasi, O. A.; Gabriele, B.; Spinelli, D., eds.; Società Chimica Italiana, Rome, Italy, 2023, 23–50. ISBN 978-88-94952-45-2. DOI: 10.17374/targets.2024.27.23. Vashchenko, B. V.; Geraschenko, O.; Grygorenko, O. O. Heterocyclic α-oxoesters
- [Collaborations](https://grygorenko.com/collaborations/) - International Collaborations Prof. Dr. Stefan WuttkeHead of Department of Functional Materials and Nanomagnetism at AGH University of Krakow Prof. Dr. Herbert WaldmannDirector at Max Planck Institute of Molecular Physiology Prof. Dr. Benjamin ListProfessor at Max-Planck-Institut für Kohlenforschung,Nobel Laureate in Chemistry (2021) Prof. Dr. Mark LevinAssociate Professor at University of Chicago Prof. Dr. Günter HaufeProfessor at
- [Presentations](https://grygorenko.com/presentations/) - Presentations Recent Advances on Unnatural Amino Acids and Their Analogs at Enamine, Kyїv, September 2024 Scientific Research at Enamine: Recent Developments,Vienna DoSChem Retreat, Vienna- Kyїv, March 2024 Physicochemical Properties of Fluorine-Containing Saturated (Hetero)cycles, ISFC-ISoFT, Québec – Kyїv, June 2023 Enamine Webinar on Scientific Publications,Kyїv, June 2023 Pharmaceutically Relevant Me2P(O)-Substituted HeterocyclesASC Meeting, August 2022 Нові підходи до синтезу sp3-збагачених
- [Teaching](https://grygorenko.com/teaching/) - Teaching The following courses are given in Ukrainian: “Modern medicines” (for Bachelor students), “Methodology of organic synthesis (aka “Advanced organic chemistry”), “Modern chemistry of natural compounds”, “Synthesis of sp3-enriched cyclic systems”, “Medicinal chemistry”, “Drug discovery”, “Statistical and combinatorial methods in chemistry” (for Master students), “Principles of fine organic synthesis”, “Novel aspects of organic and medicinal chemistry”, “Organic
- [Contacts | Links](https://grygorenko.com/contacts_links/) - Contacts Prof. Dr. Oleksandr Grygorenko Chemical Faculty, Taras Shevchenko National University of Kyiv Hetman Pavlo Skoropadskyi Street 12, 01601, Kyїv, Ukraine Tel. +38 044 239 33 15 E-mail: gregor@univ.kiev.ua; ogrygorenko@knu.ua ORCID: 0000-0002-6036-5859 Scopus ID: 6505483164 Web of Science ResearcherID: H-9942-2018 Google Scholar: Oleksandr Grygorenko ResearchGate: Oleksandr-Grygorenko Facebook Twitter Youtube Linkedin Useful Links Chemical FacultyTaras Shevchenko National University of Kyiv Organic

## Мої шаблони

- [2026](https://grygorenko.com/?elementor_library=2026) - Sidorska, V. S.; Aleksandrenko, S. H.; Doroshenko, I. O.; Vashchenko, B. V.; Zhersh, S.; Grygorenko, O. O. Cyclic sulfamates through [5 + 1] cyclization of sulfuryl fluoride and salicylic amides: synthesis and functionalization. Eur. J. Org. Chem. 2026, in press. DOI: 10.1002/ejoc.70596. Preprint: 10.26434/chemrxiv.15000251. Melnykov, K. P.; Liashuk, O. S.; Koblianskyi, A.; Smyrnov, O.; Slobodianyk, S.; Bobovskyi,
- [2025](https://grygorenko.com/?elementor_library=2025) - Fang, H.; García-Camacho, A.; Hwang, H. S.; Sudsamart, A.; Daniliuc, C. G.; Grygorenko, O. O.; Funes-Ardoiz, I.; Molloy, J. J. Boron-enabled stereoselective synthesis of polysubstituted housanes. J. Am. Chem. Soc. 2025, 147(51), 47730–47741. DOI: 10.1021/jacs.5c17624. Preprint: 10.26434/chemrxiv-2025-cgg8d. Redka, M. O.; Liashuk, O. S.; Kondratov, I. S.; Grygorenko, O. O. Practical сhiral separation of β-СF₃-α-proline. Ukr. Bioorg. Acta 2025, 20(2), 35–39.
- [2024](https://grygorenko.com/?elementor_library=2024) - Galavskyy, S.; Chernykh, A.; Liashuk, O.; Lesyk, D.; Shishkina, S. V.; Kliukovskyi, D.; Volochnyuk, D. M.; Ryabukhin, S. V.; Grygorenko, O. O. 4-Azaspiro[2.3]hexane, an overlooked piperidine isostere: multigram synthesis and physicochemical and structural evaluation. J. Org. Chem. 2024, 89(24), 18477–18486. DOI: 10.1021/acs.joc.4c02390. Liashuk, O. S.; Fedinchyk, A.; Melnykov, K. P.; Herasymchuk, M.; Alieksieieva, D.; Lesyk,
- [2023](https://grygorenko.com/?elementor_library=2023) - Omelian, T. V.; Ostapchuk, E. N.; Dobrydnev, A. V.; Grygorenko, O. O. Expedient synthesis of 6-functionalized azabicyclo[4.1.0]heptane derivatives. ChemistrySelect 2023, 8, e202304331. DOI: 10.1002/slct.202304331. Анхім, М. О.; Андріашвілі, В. А.; Жерш, С. А.; Толмачов, А. О.; Григоренко, О. О. Синтез насичених нітрогеновмісних гетероциклічних сульфінатів. Допов. Нац. Акад. Наук Укр. 2023 (5), 26–36. DOI: 10.15407/dopovidi2023.05.026. Moroz, B.; Melnykov, K. P.;
- [2020](https://grygorenko.com/?elementor_library=2020) - Yampolska H., Kharchenko S., Kozytskyi A., Kyrylchuk A., Voitenko Z., Grygorenko O. Synthesis of a 1,2,3-triazole-containing macrocycle based on the “click chemistry” reaction and analysis of its planar chirality using NMR and DFT calculations. Вісник Київського національного університету імені Тараса Шевченка. Хімія 2020, 57(1), С. 55–61. DOI: 10.17721/1728-2209.2020.1(57).14. Феськов, І. О.; Кондратов, І. С.; Кучковська,
- [2019](https://grygorenko.com/?elementor_library=2019) - Malets, Y. S.; Moskvina, V. S.; Grygorenko, O. O.; Brovarets, V. S. Synthesis of azachromones and azachromanones. Chem. Heterocycl. Compd. 2019, 55, 1007–1012. DOI: 10.1007/s10593-019-02570-x. Chalyk, B. A.; Khutorianskyi, A.; Lysenko, A.; Fil, Yu.; Kuchkovska, Yu. O.; Gavrilenko, K. S.; Bakanovych, I.; Moroz, Yu. S.; Gorlova, A. O.; Grygorenko, O. O. Regioselective synthesis of functionalized
- [2018](https://grygorenko.com/?elementor_library=2018) - Yarmoliuk, D. V.; Serhiichuk, D.; Smyrnov, V.; Tymtsunik, A. V.; Hryshchuk, O. V.; Kuchkovska, Y.; Grygorenko, O. O. Synthesis of azabicyclo[n.1.0]alkane-derived bifunctional building blocks via the Corey–Chaykovsky cyclopropanation. Tetrahedron Lett. 2018, 59, 4611–4615. DOI: 10.1016/j.tetlet.2018.11.047. Tolmachova, K. A.; Moroz, Y. S.; Konovets, A.; Platonov, M. O.; Vasylchenko, O. V.; Borysko, P.; Zozulya, S.; Gryniukova, A.;
- [2017](https://grygorenko.com/?elementor_library=2017) - Kleban, I.; Tymtsunik, A. V.; Rassukana, Y. V.; Grygorenko, O. O. O-(α-Phenylethyl)hydroxylamine as a ‘chiral ammonia equivalent’: synthesis and resolution of 5-oxopyrrolidine- and 6-oxopiperidine-3-carboxylic acids. Tetrahedron: Asymmetry 2017, 28, 1817–1822. DOI: 10.1016/j.tetasy.2017.10.027. Subota, A. I.; Volochnyuk, D. M.; Gorlova, A.; Grygorenko, O. O. Scalable synthesis and properties of 7-methyl-4-azaindole. Heterocycl. Commun. 2017, 23, 449–453. DOI:
- [2015](https://grygorenko.com/?elementor_library=2015) - Artamonov, O. S.; Bulda, T.; Fam, T. K.; Slobodyanyuk, E. Y.; Volochnyuk, D. M.; Grygorenko, O. O. A stereolibrary of conformationally restricted amino acids based on pyrrolidinyl/piperidinyloxazole motifs. Heterocycl. Commun. 2015, 21, 391–395. DOI: 10.1515/hc-2015-0137. Tymtsunik, A. V.; Ivon, Y. M.; Komarov, I. V.; Grygorenko, O. O. Synthesis of racemic and enantiopure 3,4-methanonipecotic acid. Tetrahedron:
- [2016](https://grygorenko.com/?elementor_library=2016) - Nosik, P. S.; Ryabukhin, S. V.; Artamonov, O. S.; Grygorenko, O. O. Synthesis of trans-disubstituted pyrazolylcyclopropane building blocks. Monatch. Chem. 2016, 147, 1629–1636. DOI: 10.1007/s00706-016-1726-6. Tymtsunik, A. V.; Kokhan, S. O.; Ivon, Y. M.; Komarov, I. V.; Grygorenko, O. O. Intramolecular functional group differentiation as a strategy for the synthesis of bridged bicyclic β-amino acids.
- [2014](https://grygorenko.com/?elementor_library=2014) - Ivonin, S. P.; Kurpil’, B. B.; Grygorenko, O. O.; Volochnyuk, D. M. Reaction of hydrazones derived from electron-deficient ketones with Vilsmeier-Haack reagent. Heterocycl. Commun. 2014, 20, 351–354. DOI: 10.1515/hc-2014-0176. Ryabukhin, S. V.; Fominova, K. I.; Sibgatulin, D. A.; Grygorenko, O. O. Synthesis of three-dimensional fused and spirocyclic oxygen-containing cyclobutanone derivatives. Tetrahedron Lett. 2014, 55, 7240–7242.
- [2013](https://grygorenko.com/?elementor_library=2013) - Ostapchuk E. N.; Plaskon A. S.; Grygorenko, O. O.; Tolmachev, A. A.; Ryabukhin, S. V. Protecting group free synthesis of carboxyl-substituted dihydropyrimidines through Biginelli reaction. J. Heterocycl. Chem. 2013, 50, 1299–1303. DOI: 10.1002/jhet.1568. Moriev, R.; Vasylchenko, O.; Platonov, M.; Grygorenko, O.; Volkova K.; Zozulya, S. Identification of novel IGF1R kinase inhibitors by molecular modeling and
- [2012](https://grygorenko.com/?elementor_library=2012) - Ryabukhin, S. V.; Panov, D. M.; Plaskon, A. S.; Grygorenko, O. O. Approach to the library of 3-hydroxy-1,5-dihydro-2H-pyrrol-2-ones through a three-component condensation. ACS Comb. Sci. 2012, 14, 631–635. DOI: 10.1021/co300082t. Ryabukhin, S. V.; Naumchik, V. S.; Grygorenko, O. O.; Tolmachev, A. A. Chlorotrimethylsilane-promoted condensation of ketones and aminoazoles. J. Heterocycl. Chem. 2012, 49, 1147–1150. DOI:
- [2011](https://grygorenko.com/?elementor_library=2011) - Zhersh, S., Buryanov, V. V., Karpenko, O. V., Grygorenko, O. O., Tolmachev, A. A. A library of conformationally restricted saturated heterocyclic sulfonyl chlorides. Synthesis 2011, 3669–3674. DOI: 10.1055/s-0030-1260223. Grygorenko, O. O.; Radchenko, D. S.; Volochnyuk, D. M.; Tolmachev, A. A.; Komarov, I. V. Bicyclic conformationally restricted diamines. Chem. Rev. 2011, 111, 5506–5568. DOI: 10.1021/cr100352k. Ryabukhin, S. V.; Naumchik, V. S.; Plaskon,
- [2002-2009](https://grygorenko.com/?elementor_library=2002-2009) - Tkachenko, A. N.; Radchenko, D. S.; Mykhailiuk, P. K.; Grygorenko, O. O.; Komarov, I. V. 4-Fluoro-2,4-methanoproline. Org. Lett. 2009, 11, 5674–5676. DOI: 10.1021/ol902381w. Volochnyuk, D. M.; Ryabukhin, S. V.; Plaskon, A. S.; Grygorenko, O. O. Organosilicon compounds as water scavengers in reactions of carbonyl compounds. Synthesis 2009, 3719–3743. DOI: 10.1055/s-0029-1217066. Radchenko, D. S.; Kopylova, N. A.;
- [2010](https://grygorenko.com/?elementor_library=2010) - Kopylova, N. A.; Grygorenko, O. O.; Komarov, I. V.; Groth, U. Synthesis of enantiopure (R,R)- and (S,S)-cis-2,3-propanoprolines. Tetrahedron: Asymmetry 2010, 21, 2868–2871. DOI: 10.1016/j.tetasy.2010.11.017. Denisenko, A. V.; Mityuk, A. P.; Grygorenko, O. O.; Volochnyuk, D. M.; Shishkin, O. V.; Tolmachev, A. A.; Mykhailiuk, P. K. 3-Benzyl-3-azabicyclo[3.1.1]heptan-6-one: a promising building block for medicinal chemistry. Org. Lett.
- [2021](https://grygorenko.com/?elementor_library=2021) - Grygorenko, O. O. Enamine Ltd.: the science and business of organic chemistry and beyond. Eur. J. Org. Chem. 2021, 6474–6477. DOI: 10.1002/ejoc.202101210. (Featured by Cover Picture). Vaskevych, A. I.; Savinchuk, N. O.; Vaskevych, R. I.; Rusanov, E. B.; Grygorenko, O. O.; Vovk, M. V. The PIFA-initiated oxidative cyclization of 2-(3-butenyl)quinazolin-4(3H)-ones – an efficient approach to
- [2022](https://grygorenko.com/?elementor_library=2022) - Kondratov, I. S.; Moroz, Y. S.; Gorgulla, C.; Grygorenko, O. O.; Komarov, I. V.; Wagner, G.; Tolmachev, A. A. Challenges for chemistry in Ukraine after the war: Ukrainian science requires rebuilding and support. Proc. Natl. Acad. Sci. USA 2022, 119, e2210686119. DOI: 10.1073/pnas.2210686119. Yarish, D.; Garkot, S.; Grygorenko, O. O.; Radchenko, D. S.; Moroz, Y. S.; Gurbych, O. Advancing
- [Papers](https://grygorenko.com/?elementor_library=початковий-набір)